Hyaluronic acid modified extracellular vesicles targeting hepatic stellate cells to attenuate hepatic fibrosis

• DOI: 10.1016/j.ejps.2024.106783
• Publication Date: 2024-05-03T01:36:26Z
• Authors: Fei Yu; Zongyu Liu; Jie Feng; Yuhong Man; Huan Zhang; Jingying Shi; Xiang Pang; Yang Yu; Ye Bi
• Keywords: Hepatic stellate cell; Extracellular Vesicles; Hepatic fibrosis

Transforming growth factor-beta1 (TGF-β1) plays a pivotal role in promoting hepatic fibrosis, pirfenidone (PFD) could inhibit TGF-β1 signaling pathway to alleviate stellate cells (HSC) activation mediated fibrosis. The targeting delivery strategy of PFD is challenge. Extracellular vesicles (EVs), cell-derived membranous particles are intraluminal nano-vesicles that play vital intercellular communication, they also be considered as an ideal nano-carrier.