Clinical implication of tumor site in terms of node metastasis for intrahepatic cholangiocarcinoma

• DOI: 10.1016/j.ejso.2019.11.511
• Publication Date: 2019-11-28T18:07:03Z
• Authors: Woohyung Lee; Chi-Young Jeong; Jae Yool Jang; Young Hoon Roh; Kwan Woo Kim; Sung Hwa Kang; Myung Hee Yoon; Hyung Il Seo; Jeong-Ik Park; Bo-Hyun Jung; Dong Hoon Shin; Young Il Choi; Hyung Hwan Moon; Je Ho Ryu; Kwangho Yang; Chang Soo Choi; Yo-Han Park; Yang Won Nah; Ryounggo Kim; Jonathan Navarro; Dae-Hoon Han; Gi Hong Choi; Chang Moo Kang; Kyung-Sik Kim; Soon-Chan Hong
• Keywords: Intrahepatic Cholangiocarcinoma

The clinical implication of lymph node (LN) dissection intrahepatic cholangiocarcinoma (ICCA) is still controversial, and LN metastasis (LNM) based on tumor site has not been confirmed yet.Patients who underwent curative-intent surgery at 10 tertiary referral centers were identified divided into peripheral (PP) near second confluence level (NC) groups the basis distance from oncological outcomes compared.Of 179 patients, 121 patients with LND NC (n = 89) PP 32) 4.5 cm confluence. group showed higher LNM rate than (46.1 vs 21.9%, p 0.016) was a risk factor for (odds ratio: 4.367; 95% confidence interval: 1.234-15.453, 0.022). 5-year overall survival (OS) (38.0% vs. 27.8%, 0.777) recurrence-free (RFS) rates (22.8% 25.8%, 0.742) no differences between groups. In group, N1 worse OS (12.7% 39.0%, 0.004) RFS (8.8% 28.6%, N0 patients. discordant results in (48.9% 50.0%, 0.462) (41.3% 0%, 0.056) found patients.The an independent worsened prognosis ICCA. should be omitted because high insufficient oncologic evidence.