Simultaneous approach for patients with synchronous colon and rectal liver metastases: Impact of site of primary on postoperative and oncological outcomes

• DOI: 10.1016/j.ejso.2020.09.015
• Publication Date: 2020-09-25T21:25:59Z
• Authors: Simone Conci; Andrea Ruzzenente; Corrado Pedrazzani; Giulia Isa; Giulia Turri; Tommaso Campagnaro; Alessandro Valdeg...; Fabio Bagante; Ivan Marchitelli; Alfredo Guglielmi
• Keywords: Synchronous colorectal liver metastases; Male; Liver and colorectal resection; Neoplasm, Residual; Time Factors; Antineoplastic Agents; Simultaneous approach synchronous liver metastases; Colon, Ascending; 03 medical and health sciences; Postoperative Complications; 0302 clinical medicine; Colon, Sigmoid; Humans; Rectal cancer; Aged; Neoplasm Staging; Rectal Neoplasms; Liver Neoplasms; Combined resection; Middle Aged; Neoadjuvant Therapy; 3. Good health; Colon, Descending; Survival Rate; Chemotherapy, Adjuvant; Colonic Neoplasms; Primary tumor location; Female; Radiotherapy, Adjuvant

We aimed to investigate the impact of the site of the primary on postoperative and oncological outcomes in patients undergone simultaneous approach for colon (CC) and rectal cancer (RC) with synchronous liver metastases (SCRLM).Of the 220 patients with SCRLM operated on between Mar 2006 and Dec 2017, 169 patients (76.8%) were treated by a simultaneous approach and were included in the study. Two groups were considered according to the location of primary tumor RC-Group (n = 47) and CC-group (n = 122).Multiple liver metastases were observed in 70.2% in RC-Group and 77.0% in CC-Group (p = 0.233), whilst median Tumor Burden Score (TBS) was 4.7 in RC-Group and 5.4 CC-Group (p = 0.276). Severe morbidity (p = 0.315) and mortality at 90 days (p = 0.520) were comparable between RC-Group and CC-Group. The 5-year overall survival (OS) rate was similar comparing RC-Group and CC-Group (48.2% vs. 45.3%; p = 0.709), but it was significantly different when considering left-CC, right-CC and RC separately (54.5% vs. 35.2% vs. 48.2%; p = 0.041). Primary tumor location (right-CC, p = 0.001; RC, p = 0.002), microscopic residual (R1) disease at the primary (p < 0.001), TBS ≥6 (p = 0.012), bilobar metastases (p = 0.004), and chemotherapy strategy (preoperative ChT, p = 0.253; postoperative ChT, p = 0.012; and perioperative ChT, p < 0.001) resulted to be independent prognostic factors at multivariable analysis.In patients with SCRLM, simultaneous resection of the primary tumor and liver metastases seems feasible and safe and allows satisfactory oncological outcomes both in CC and RC. Right-CC shows a worse prognosis when compared to left-CC and RC.