Impact of multicentre diagnostic workup in patients with pancreatic cancer on repeated diagnostic investigations, time-to-diagnosis and time-to-treatment: A nationwide analysis

• DOI: 10.1016/j.ejso.2022.05.031
• Publication Date: 2022-06-02T16:21:17Z
• Authors: Jana S. Hopstaken; Pauline A.J. Vissers; Rutger Quispel; Judith de Vos-Geelen; Lodewijk A.A. Bro...; Ignace H.J.T. de ...; Lydia G. van der ...; Marc G. Besselink; Kees J.H.M. van L...; Martijn W.J. Stommel
• Keywords: Pathology - Radboud University Medical Center; Radboudumc 14: Tumours of the digestive tract RIHS: Radboud Institute for Health Sciences; 3. Good health; Pancreatic Neoplasms; 03 medical and health sciences; Radboudumc 14: Tumours of the digestive tract RIMLS: Radboud Institute for Molecular Life Sciences; 0302 clinical medicine; Humans; Pancreas; Surgery - Radboud University Medical Center; Retrospective Studies; Carcinoma, Pancreatic Ductal

Due to the centralization of pancreatic surgery, patients with suspected cancer may undergo diagnostic workup in both a non-pancreatic centre and centre, i.e. multicentre workup. This retrospective study assessed whether is associated repeated diagnostics, delayed time-to-diagnosis, time-to-treatment, survival variation existed among networks.This nationwide included all diagnosed non-metastatic ductal adenocarcinoma (PDAC) 2015, registered by Netherlands Cancer Registry. A time-to-diagnosis was defined as ≥3 weeks from initial hospital visit final diagnosis. time-to-treatment ≥6 first start tumour treatment. Multilevel logistic regression analyses were performed.In total, 931 PDAC included. Overall, 175 (19%) underwent workup, which significantly investigations (OR = 6.31, 95% CI 4.13-9.64, P < 0.0001), 2.66 1.74-4.06, 0.001), 1.93 1.12-3.31, 0.02), but not decreased (HR 1.09 0.83-1.44; 0.532). Variation outcomes per network observed, especially for though ICC statistically significant (P 0.065).Multicentre investigations, compared monocentre To reduce costs improve treatment times, efforts should be made coordination, example via care pathways.