Cystatin C Predicts Renal Recovery Earlier Than Creatinine Among Patients With Acute Kidney Injury

• DOI: 10.1016/j.ekir.2017.10.012
• Publication Date: 2017-11-04T00:46:30Z
• Authors: Kamel A. Gharaibeh; Abdurrahman M. Ha...; Ziad M. El-Zoghby; John C. Lieske; Timothy S. Larson; Nelson Leung
• Keywords: Acute tubular necrosis

IntroductionSerum cystatin C increases earlier than creatinine during acute kidney injury. However, whether decreases recovery is unknown. This retrospective study aimed to determine the temporal trend between and in injury.MethodsWe identified hospitalized patients with nonoliguric injury who had serial values measured May 2015 2016. Demographic laboratory data, causes of injury, relevant comorbidity data were collected through chart review.ResultsFor 63 patients, mean (SD) age was 58.7 (13.9) years; male sex, 62%; white race/ethnicity, 95%. Baseline median (range) 1.1 (0.5–3.0) mg/dl; 13% transplant recipients 37% received corticosteroids. Comorbidities included malignancy (38%), diabetes mellitus (33%), heart failure (19%), thyroid disorder (16%). The cause tubular necrosis 71%, 61% stage III, 33% required dialysis. Cystatin began decrease before 68% patients: 1 day earlier, 46%; 2 days 16%; 3 6%. In 24% cases, both decreasing on same day; only 8%, decreased after creatinine. Overall, (95% confidence interval) 0.92 (0.65–1.18) (P < 0.001).ConclusionIn summary, most If confirmed large prospective studies, these findings may have important management implications, possibly shortening hospital stay reducing costs.