Risk of breast cancer associated with long-term exposure to benzo[a]pyrene (BaP) air pollution: Evidence from the French E3N cohort study

• DOI: 10.1016/j.envint.2021.106399
• Publication Date: 2021-01-24T16:57:51Z
• Authors: Amina Amadou; Delphine Praud; Thomas Coudon; Floriane Deygas; Leny Grassot; Elodie Faure; Florian Couvidat; Julien Caudeville; Bertrand Bessagnet; Pietro Salizzoni; John Gulliver; Karen Leffondré; Gianluca Severi; Francesca Romana ...; Béatrice Fervers
• Keywords: Interquartile range

Benzo[a]pyrene (BaP) is an endocrine-disrupting pollutant formed during incomplete combustion of organic materials. It has been recognized as a reproductive and developmental toxicant, however epidemiological evidence the long-term effect ambient air BaP on breast cancer (BC) limited. Thus we evaluated associations between exposure risk BC, overall according to menopausal status molecular subtypes (estrogen receptor negative/positive (ER−/ER+) progesterone (PR−/PR+)), stage grade differentiation BC in French E3N cohort study. Within nested case-control study 5222 incident cases matched controls, annual was estimated using chemistry-transport model (CHIMERE) assigned geocoded residential addresses participants for each year 1990–2011 follow-up period. Multivariable conditional logistic regression models were used estimate odds ratios (ORs) 95% confidence intervals (CIs). Overall, cumulative airborne significantly associated with 1 interquartile range (IQR) increase concentration levels (1.42 ng/m3), OR = 1.15 (95% CI: 1.04–1.27). However, by status, significant positive association remained only women who underwent transition (i.e. premenopausal at inclusion became postmenopausal diagnosis), per IQR 1.20 1.03–1.40). By hormone observed ER+, PR + ER ORs 1.17 1.04–1.32), 1.16 1.01–1.33), 1.01–1.36) IQR, respectively. There also borderline 3 (OR 0.99–1.34). We provide increased exposure, which varied BC. Our results add further previous experimental studies suggesting adverse effects BaP.