Contribution of trace element exposure to gestational diabetes mellitus through disturbing the gut microbiome

• DOI: 10.1016/j.envint.2021.106520
• Publication Date: 2021-03-26T13:06:06Z
• Authors: Yuqing Zhang; Ting Chen; Yiyun Zhang; Qi Hu; Xu Wang; Hang Chang; Jian-Hua Mao; Antoine M. Snijders; Yankai Xia
• Keywords: Lachnospiraceae; Roseburia

A healthy gut microbiome is critical for glucose metabolism during pregnancy. In vivo studies indicate that trace element affects the composition and function of potentially leads to metabolic disorders but their relationships are largely unknown. We aimed investigate whether plays a role in relationship between exposure gestational diabetes mellitus (GDM).In prospective cohort study, serum levels 22 elements fecal were assessed 837 pregnant women second trimester 24 weeks pregnancy prior GDM diagnosis. Regression mediation analysis used explore link exposure, microbiome, GDM.128 (15.3%) diagnosed with GDM. No individual found significantly associated contrast, was dramatically altered later characterized by lower alpha diversity abundance co-abundance groups (CAGs) composed genera belonging Ruminococcaceae, Coriobacteriales, Lachnospiraceae. Rubidium (Rb) positively indices while mercury (Hg) vanadium (V) showed negative associations. Elements including rubidium (Rb), thallium (Tl), arsenic (As), antimony (Sb) correlated GDM-related CAGs revealed Rb Sb inversely related risk altering enriched Lachnospiraceae, Ruminococcaceae.Our study indicates specific features may contribute development, which could provide new avenue intervening environmental exposure-related