Relationship between acute kidney injury, seasonal influenza, and environmental factors: A 14-year retrospective analysis

• DOI: 10.1016/j.envint.2021.106521
• Publication Date: 2021-04-02T21:34:57Z
• Authors: Kirran N. Mohammad; Emily Ying Yang Chan; Steven Yuk-Fai Lau; Holly Ching Yu Lam; William Bernard G...; Ka Chun Chong
• Keywords: Air Pollutants; Air pollution; Distributed-lag non-linear model; Acute Kidney Injury; 01 natural sciences; Acute kidney injury; 3. Good health; Environmental sciences; Hospitalization; Subtropics; Air Pollution; Influenza, Human; Hong Kong; Humans; GE1-350; Seasons; Ambient temperature; Seasonal influenza; Retrospective Studies; 0105 earth and related environmental sciences

Despite high incidence of acute kidney injury (AKI) among patients hospitalised for influenza, no previous work has attempted to analyse and quantify the association between two. Herein, we made use Hong Kong's surveillance data evaluate time-varying relationship seasonal influenza risk AKI with adjustment potential environmental covariates. Generalized additive model was used in conjunction distributed-lag non-linear estimate interest daily admissions as outcome predictor, while controlling variables (i.e. temperature, relative humidity, total rainfall, nitrogen dioxide, ozone). Results suggested a positive admission number hospitalisation cases, reaching 1.12 (95% confidence interval, 1.10-1.15) at 95th percentile. Using median reference, an almost U-shaped temperature observed; increased significantly when low. While ozone not shown be factor AKI, moderate-to-high levels dioxide (50-95th percentile) were associated admission. This study mentioned possibility that hospitalisations are subject influences offered support occurrence Kong. Authorities urged extend vaccination program individuals pre-existing renal conditions safeguard health vulnerable. Given adverse effects evident current ambient government is recommended adopt clean-air policies earliest opportunity protect community.