Urinary metabolic characterization with nephrotoxicity for residents under cadmium exposure

• DOI: 10.1016/j.envint.2021.106646
• Publication Date: 2021-05-26T04:54:48Z
• Authors: Ting Zeng; Yanshan Liang; Jinyao Chen; Guodong Cao; Zhu Yang; Xingchen Zhao; Jinglin Tian; Xiong Xin; Bo Lei; Zongwei Cai
• Keywords: Nephrotoxicity; Creatine; Metabolic pathway; CADMIUM EXPOSURE

Cadmium is a well-known hazardous pollutant that mainly comes from dietary, tobacco and occupational exposure, posing threat to kidney. However, there still lack of systematic study on metabolic pathways urinary biomarkers related its nephrotoxicity under cadmium exposure for both females males. In this study, mass spectrometry-based metabolomics investigation cohort 144 volunteers was conducted explore sex-specific alteration screen cadmium-induced nephrotoxicity. When the concentration increased, creatine pathway, amino acid metabolism especially tryptophan metabolism, aminoacyl-tRNA biosynthesis, purine were primarily influenced regardless gender. Also, most specific linked with based statistical analysis detected including creatine, creatinine, l-tryptophan, adenine uric acid. The outcome might provide information reflect body burden help improve health policy risk assessment.