Prenatal and postnatal exposures to four metals mixture and IQ in 6-year-old children: A prospective cohort study in South Korea

• DOI: 10.1016/j.envint.2021.106798
• Publication Date: 2021-07-30T18:50:54Z
• Authors: Kyung-Shin Lee; Kyoung-Nam Kim; Yebin D. Ahn; Yoon-Jung Choi; Jinwoo Cho; Yoonyoung Jang; Youn-Hee Lim; Johanna Inhyang Kim; Choong Ho Shin; Young Ah Lee; Bung-Nyun Kim; Yun-Chul Hong
• Keywords: Quartile

Humans are exposed to a mixture of metals during their lifetime; however, evidence neurotoxicity such mixtures in critical time windows is still insufficient. We aimed elucidate the associations four across multiple points with children's intelligence quotient (IQ) prospective cohort study.Prenatal exposure and at age 4 6 years types blood metals, namely lead, mercury, cadmium, manganese were quantified 502 pregnant women children who participated Environment Development Cohort study. Children' s IQ scores assessed using Wechsler Intelligence Scale 6. Bayesian kernel machine regression (BKMR), quantile g-computation models, elastic net (ENET) models used assess scores.Multivariate linear indicated that postnatal was significantly negatively associated [β = - 5.99, 95% confidence interval (CI): -11.37 0.61]. In multi-chemical BKMR model, statistically significant inverse found between prenatal score (Difference children' per quartile increase: -2.83; CI: -5.28, -0.38). Interestingly, we levels both contributing factors namely, BKMR, g-computation, ENET models.Multi-pollutant exposures affected child age. relationship 4, IQ. Additional studies warranted confirm these control different pregnancy preschool childhood.