Associations between long-term exposure to low-level air pollution and risk of chronic kidney disease—findings from the Malmö Diet and Cancer cohort

• DOI: 10.1016/j.envint.2022.107085
• Publication Date: 2022-01-15T16:08:52Z
• Authors: Yiyi Xu; Eva M Andersson; Hanne Krage Carlsen; Peter Molnár; Susanna Gustafsson; Sandra Johannesson; Anna Oudin; Gunnar Engström; Anders Christensson; Leo Stockfelt
• Keywords: Interquartile range

Associations between air pollution and chronic kidney disease (CKD) have been reported, but studies at low exposure levels relevant time windows are still warranted. This study investigated clinical CKD in the Swedish Malmö Diet Cancer Cohort different windows.This included 30,396 individuals, aged 45-74 enrollment 1991-1996. Individual annual average residential outdoor PM2.5, PM10, nitrogen oxides (NOx), black carbon (BC) were assigned using dispersion models from to 2016. Diagnoses of incident retrieved national registries. Cox proportional hazards used obtain hazard ratios (HRs) for relation three time-dependent windows: concurrent year (lag 0), mean 1-5 or 6-10 preceding years lag 6-10), baseline exposure.During period, exposures 16 μg/m3 11 26 NOx, 0.97 BC. For exposure, significantly elevated HRs found total PM10:1.13 (95% CI: 1.01-1.26) 1.22 (1.06-1.41); NOx: 1.19 (1.07-1.33) 1.13 (1.02-1.25) BC: 1.12 (1.03-1.22) 1.11 (1.02-1.21) per interquartile range increase exposure. PM2.5 positive associations (0.97-1.31) 1.16 (0.98-1.36) not significant. 0 there significant only NOx BC, PM.Residential was associated with increased risk relatively levels. Average long-term more clearly than current recruitment. Our findings imply that health effects low-level on considerable.