Antimicrobial resistance in dairy slurry tanks: A critical point for measurement and control

• DOI: 10.1016/j.envint.2022.107516
• Publication Date: 2022-09-13T16:08:20Z
• Authors: Michelle Baker; Alexander D. Will...; Steven P.T. Hooton; Richard Helliwell; Elizabeth King; Thomas Dodsworth; Rosa María Baena-...; Andrew Warry; Catherine A. Ortori; Henry Todman; Charlotte J. Gray...; Alexander C.W. Pr...; Ethan Iles; Ryan Cook; Richard D. Emes; Michael A. Jones; Theodore Kypraios; Helen West; David A. Barrett; Stephen J. Ramsden; Rachel L. Gomes; Chris Hudson; Andrew D. Millard; Sujatha Raman; Carol Morris; Christine E.R. Dodd; Jan-Ulrich Kreft; Jon L. Hobman; Dov J. Stekel
• Keywords: 0301 basic medicine; 2. Zero hunger; Slurry; Angiotensin-Converting Enzyme Inhibitors; Antimicrobial resistance; Microbiology; Anti-Bacterial Agents; Cephalosporins; Dairy; Environmental sciences; Angiotensin Receptor Antagonists; 03 medical and health sciences; Mathematical model; Drug Resistance, Bacterial; Escherichia coli; Humans; GE1-350

Waste from dairy production is one of the largest sources contamination antimicrobial resistant bacteria (ARB) and genes (ARGs) in many parts world. However, studies to date do not provide necessary evidence inform resistance (AMR) countermeasures. We undertook a detailed, interdisciplinary, longitudinal analysis slurry waste. The contained population ARB ARGs, with resistances current, historical never-used on-farm antibiotics; were associated Gram-negative Gram-positive mobile elements (ISEcp1, Tn916, Tn21-family transposons). Modelling experimental work suggested that these populations are dynamic equilibrium, microbial death balanced by fresh input. Consequently, storing without further waste input for at least 60 days was predicted reduce spread onto land, > 99 % reduction cephalosporin Escherichia coli. model also indicated farms low antibiotic use, reductions unlikely AMR further. conclude tank critical point measurement control AMR, actions limit should combine responsible including total quantity, avoidance human antibiotics, choosing antibiotics shorter half-lives, coupled appropriate storage.