Impacts of net cages on pollutant accumulation and its consequence on antibiotic resistance genes (ARGs) dissemination in freshwater ecosystems: Insights for sustainable urban water management

• DOI: 10.1016/j.envint.2023.108357
• Publication Date: 2023-11-28T08:01:34Z
• Authors: Min Wang; Abolfazl Masoudi; Can Wang; Changhao Wu; Ze Zhang; Xin Zhao; Yuanjie Liu; Zhijun Yu; Jingze Liu
• Keywords: Resistome; Marine ecosystem

There has been increasing interest in the role of human activities disseminating antibiotic-resistance genes (ARGs) aquatic ecosystems. However, influence pollutant accumulation on anthropogenic pollutant-ARG synergistic actions is limited. This study explored association net cages with propagation pollutants and their consequences for influencing enrichment ARGs using high-throughput metagenomic sequencing. We showed that could substantially impact ecology freshwater systems by enhancing i) ARG diversity tendency ARG-horizontal gene transfer ii) overlap mobile genetic elements (MGEs) biocide-metal resistance (BMRGs) ARGs. These findings suggested cotransfer these three determinants would be favored cage plots nonantibiotic factors such as metal(loid)s, particularly iron (Fe), displayed robust selective pressures exerted cage. The resistome risk scores sediments biofilms were higher than those from off-net plots, indicating cage-origin antibiotic should great concern. combination deterministic stochastic processes acting bacterial communities explain variations (8.2%) off-cage (3.4%). Moreover, MGEs together explained 43.3% total variation communities, which was (8.8%), considering pollutants, environmental variables, MGEs, assembly processes. will inform development policies guidelines to more effectively limit spread antimicrobial achieve goal sustainability urban areas.