Fetal bisphenol and phthalate exposure and early childhood growth in a New York City birth cohort

• DOI: 10.1016/j.envint.2024.108726
• Publication Date: 2024-05-08T01:55:42Z
• Authors: Sophia M. Blaauwe...; Sarvenaz Shahin; Carol Duh-Leong; Mengling Liu; Kurunthachalam Ka...; Linda G. Kahn; Vincent W.V. Jaddoe; Akhgar Ghassabian; Leonardo Trasande
• Keywords: Fetal growth

Exposure to endocrine-disrupting chemicals such as bisphenols and phthalates during pregnancy may disrupt fetal developmental programming influence early-life growth. We hypothesized that prenatal bisphenol phthalate exposure was associated with alterations in adiposity through 4 years. This associations might change over time. Among 1091 mother–child pairs a New York City birth cohort study, we measured maternal urinary concentrations of at three time points child weight, height, triceps subscapular skinfold thickness ages 1, 2, 3, used linear mixed models assess individual grouped overall time-point-specific outcomes from observed higher second trimester total A weight between years only (Beta 0.10 (95 % confidence interval 0.04, 0.16) 0.07 (0.02, 0.12) standard deviation score (SDS) per natural log increase exposure), reported an interaction the exposures time, analysis showed pregnancy-averaged mono-(2-carboxymethyl) 3 (0.14 (0.06, 0.22)), high-molecular-weight phthalate, di-2-ethylhexyl mono-(2-ethyl-5-carboxypentyl) mono-(2-ethylhexyl) (0.16 (0.04, 0.28), 0.15 (0.03, 0.27), 0.19 (0.07, 0.31), 0.16 0.24), 0.11 0.19)). Higher mono-(2-ethyl-5-hydroxyhexyl) mono-2(ethyl-5-oxohexyl) were BMI (0.20 (0.05, 0.35), 0.20 0.22 0.37), 0.34), 0.34)). For thicknesses, no associations. study contributes evidence suggesting on childhood BMI.