ALKBH5-mediated N6-methyladenosine modification of HO-1 mRNA regulates ferroptosis in cobalt-induced neurodegenerative damage

• DOI: 10.1016/j.envint.2024.108897
• Publication Date: 2024-07-20T16:21:48Z
• Authors: Qianqian Su; Lingyan Wu; Chunyan Zheng; Xianqi Ji; Xinpei Lin; Yu Zhang; Fuli Zheng; Zhenkun Guo; Wenya Shao; Hong Hu; Jinfu Zhou; Yu Jiang; Ying Tang; Siying Wu; Michael Aschner; Huangyuan Li; Guangxia Yu
• Keywords: N6-Methyladenosine

The utilization of Cobalt (Co) has surged due to it is critical role in renewable energy technologies and other high-tech applications. Concurrently, the potential health risks associated with Co exposure have raised concerns. Previous studies, including our own, shown that can impair learn memory functions as an epigenetic hazard, even at low concentrations. In this study, we explore mechanisms Co-induced ferroptosis neurodegenerative damage both vivo vitro, focusing on regulation by N6-methyladenosine (m