Silicone injection-induced granuloma formation, hypercalcemia and nephrolithiasis: a case report

• DOI: 10.1016/j.eucr.2021.101563
• Publication Date: 2021-01-12T21:02:22Z
• Authors: Albert S. Ha; Rainjade Chung; Samantha Thorogood; David M. Weiner; Ojas Shah; Kelly A. Healy
• Keywords: Etiology; Histopathology; Granulomatous disease; Granuloma formation

Hypercalcemia and nephrolithiasis have been associated with various etiologies, including dysregulation of the parathyroid glands, malignancies, or sarcoidosis. Other causes hypercalcemia, such as granulomatous disease resulting from silicone-based cosmetic injections, reported but without specific emphasis on nephrolithiasis. Herein, we report an unusual case simultaneous bilateral obstructing ureteral calculi (SBUC) triggered by recalcitrant hypercalcemia due to injections. A careful surgical history, physical exam, imaging identified underlying etiology, which was confirmed final histopathology. Using a multidisciplinary approach, patient's condition successfully managed endoscopic procedures concurrent corticosteroid therapy.