Solitary fibrous tumor of the prostate with accompanying low-grade prostate cancer

• DOI: 10.1016/j.eucr.2024.102879
• Publication Date: 2024-11-06T08:23:18Z
• Authors: Marie-Lisa Eich; Kira Furlano; Georg Hilfenhaus; Bernhard Ralla; Ulrich Keilholz; Maria Joosten; Damian T. Rieke; Thorsten Schlomm; David Horst; Simon Schallenberg
• Keywords: 0301 basic medicine; 03 medical and health sciences; Prostate cancer; Oncology; Prostate; RC870-923; SFT; Diseases of the genitourinary system. Urology; Solitary fibrous tumor; Multiple primary cancers

We present the rare case of a 51-year-old male diagnosed with a solitary fibrous tumor (SFT) of the prostate, along with a concurrent low-grade prostate adenocarcinoma (Gleason score 3 + 3, Grade Group 1). The diagnosis was confirmed by positive immunohistochemical markers, including CD34, BCL2, and STAT6, and molecular analysis showing a NAB2-STAT6 fusion. Following successful surgical management and the simultaneous diagnosis of a pulmonary relapse from a prior thyroid carcinoma, the patient remains under clinical surveillance. This is particularly significant given the patient's history of multiple tumors, including Hodgkin's lymphoma, papillary thyroid carcinoma, prostate cancer, and SFT.