Changes of the Collagen composition in the heart caused by microcurrent application. An explanation for the improvement of cardiac function by bi-ventricular pacing?

• DOI: 10.1016/j.eupc.2005.02.041
• Publication Date: 2005-05-05T12:01:32Z
• Authors: G V Knyshov; V. Zalevskyy; Olga V. Rasputniak; В. П. Захарова; V. M. Beshlyaga; Borys B. Kravchuk; M. Dyrda; L. Dzachoeva; Y. Nastenko; Y. Bilinskyy

ObjectiveImprovement of cardiac function by the unloading effect a assist device mainly depends on duration heart failure (HF). Patients with short history HF (< 5years) show improvement due to reverse remodeling myocytes and in particular collagen composition extracellular matrix. In contrast, one reason why patients longterm (> 5 years) do not significant is that matrix irreversible.It successful clinical practice apply microcurrent bone fractures wound healing disturbances order improve process modulation synthesis.In examine whether can also influence synthesis myocardium, application adult cardiomyocytes was investigated.