Transforming growth factor-β, MAPK and Wnt signaling interactions in colorectal cancer

• DOI: 10.1016/j.euprot.2015.06.004
• Publication Date: 2015-07-04T14:06:45Z
• Authors: Harish R. Cheruku; Abidali Mohamedali; David I. Cantor; Sock Hwee Tan; Edouard C. Nice; Mark S. Baker
• Keywords: Crosstalk; Smad2 Protein

In non-cancerous cells, transforming growth factor-β (TGFβ) regulates cellular responses primarily through Smad signaling. However, during cancer progression (including colorectal) TGFβ promotes tumoral via Smad-independent mechanisms and is involved in crosstalk with various pathways like the mitogen-activated protein kinases (MAPK) Wnt. Crosstalk between these following activation by subsequent downstream signaling activity can be referred to as a signature. This review highlights progress understanding involving MAPK pathway members (e.g., extracellular signal-regulated kinase (Erk) 1/2, Ras, c-Jun N-terminal (JNK) p38) Wnt pathway.