Effectiveness of phytoconstituents and potential of phyto-nanomedicines combination to treat osteoarthritis

• DOI: 10.1016/j.eurpolymj.2024.113243
• Publication Date: 2024-06-22T04:51:17Z
• Authors: Laxmi Akhileshwar...; Mohammad Imran; Jesus Shrestha; Hari Prasad Devkota; Kunal Bhattacharya; Abdulrhman Alsayari; Shadma Wahab; Saurav Kumar Jha; Keshav Raj Paudel; Prashant Kesharwani

Osteoarthritis (OA) is a well-known degenerative joint disease recognized by the deterioration of cartilage in joints, leading to pain and reduced mobility. Traditional treatments for OA include management, physical therapy, severe cases, replacement surgery. In recent years, there has been growing interest exploring potential phytoconstituents nanomedicines combined treating OA. Furthermore, with increasing amount study this field, now opportune time widespread use plant-derived medications as complementary alternative medical therapies be acknowledged used more efficient treatment human ailments like Combining nanomedicine technology (phyto-nanomedicine) can potentially enhance their effectiveness The phyto-nanomedicines many advantages, including enhanced permeability, increased bioavailability, sustained/controlled drug release at site, decreased adverse effects, possible combination treatment. It's important note that while promising preclinical some clinical evidence regarding phyto-nanomedicine treatment, further research needed establish safety efficacy conclusively. review, treat combining phytomedicines nanoparticulate delivery former therapeutic discussed detail. we have also described briefly on application organ-on-chip and/or on-chip models accelerate identification novel evaluate potency