Genetic Progression of High Grade Prostatic Intraepithelial Neoplasia to Prostate Cancer

• DOI: 10.1016/j.eururo.2015.10.031
• Publication Date: 2015-11-04T19:05:56Z
• Authors: Seung-Hyun Jung; Sun Shin; Min Sung Kim; In-Pyo Baek; Ji Youl Lee; Sung Hak Lee; Tae-Min Kim; Sug Hyung Lee; Yeun-Jun Chung
• Keywords: Comparative genomic hybridization; Chromoplexy; Chromothripsis

Although high grade prostatic intraepithelial neoplasia (HGPIN) is considered a neoplastic lesion that precedes prostate cancer (PCA), the genomic structures of HGPIN remain unknown.Identification landscape and differences between PCA may drive progression to PCA.We analyzed 20 regions paired from six patients using whole-exome sequencing array-comparative hybridization.Somatic mutation copy number alteration (CNA) profiles were measured compared.The total mutations CNAs HGPINs significantly fewer than those PCAs. Mutations in FOXA1 (1q 8q gains) detected both ('common'), suggesting their roles early development. SPOP, KDM6A, KMT2D 'PCA-specific', PCA. The 8p loss was either 'common' or 'PCA-specific'. In-silico estimation evolutionary ages predicted genomes much younger genomes. Our data show PCAs are direct descendants most cases require more alterations progress nature heterogeneous population might attenuate signals should further be studied.HGPIN harbor relatively but additional hits for progression.In this study, we suggest systemic diagram (PCA). results provide clue explain long latency useful information genetic diagnosis