Prostatic Artery Embolisation Versus Transurethral Resection of the Prostate for Benign Prostatic Hyperplasia: 2-yr Outcomes of a Randomised, Open-label, Single-centre Trial

• DOI: 10.1016/j.eururo.2021.02.008
• Publication Date: 2021-02-21T08:19:29Z
• Authors: Dominik Abt; Gautier Müllhaupt; Lukas Hechelhammer; Stefan Markart; Sabine Güsewell; Hans-Peter Schmid; Livio Mordasini; Daniel S. Engeler
• Keywords: Male; Prostate; Prostatic Hyperplasia; Transurethral Resection of Prostate; Arteries; Embolization, Therapeutic; 3. Good health; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Lower Urinary Tract Symptoms; Humans

Prostatic artery embolisation (PAE) for the treatment of lower urinary tract symptoms secondary to benign prostatic obstruction (LUTS/BPO) still remains under investigation. To compare efficacy and safety PAE transurethral resection prostate (TURP) in LUTS/BPO at 2 yr follow-up. A randomised, open-label trial was conducted. There were 103 participants aged ≥40 with refractory LUTS/BPO. versus TURP. International Prostate Symptoms Score (IPSS) other questionnaires, functional measures, volume, adverse events evaluated. Changes from baseline tested differences between two interventions standard two-sided tests. The mean reduction IPSS after 9.21 points 12.09 TURP (difference 2.88 [95% confidence interval 0.04–5.72]; p = 0.047). Superiority also found most patient-reported outcomes except erectile function. less effective than regarding improvement maximum flow rate (3.9 vs 10.23 ml/s, difference –6.33 [–10.12 –2.54]; < 0.001), postvoid residual urine (62.1 204.0 ml; 141.91 [43.31–240.51]; 0.005), volume (10.66 30.20 19.54 [7.70–31.38]; 0.005). Adverse frequent (total occurrence n 43 78, but distribution among severity classes similar. Ten patients (21%) who initially underwent required within due unsatisfying clinical outcomes, which prevented further assessment their and, therefore, represents a limitation study. Inferior improvements relevant re-treatment are compared is associated fewer complications disadvantages should be considered patient selection counselling. safe effective. However, prostate, its subjective objective individual choices.