In vitro anthelmintic activity of aqueous leaf extract of Annona muricata L. (Annonaceae) against Haemonchus contortus from sheep

• DOI: 10.1016/j.exppara.2013.03.032
• Publication Date: 2013-04-10T01:20:12Z
• Authors: L.E. Ferreira; P.M.N. Castro; A.C.S. Chagas; S.C. França; R.O. Beleboni
• Keywords: Annona muricata; Phytochemical; Aqueous extract

Despite the overall progress of sheep farming in Brazil, infections with gastrointestinal parasite Haemonchus contortus represent one most important problems production, aggravated by increasing resistance nematodes to traditional anthelmintic drugs caused inadequate flock management breeders. Ethnopharmacological data indicate Annona muricata as a promising alternative for control because its general properties. The aim this work was evaluate vitro effects A. aqueous leaf extract against eggs, infective larvae and adult forms parasitic nematode H. contortus. At higher doses, showed 84.91% 89.08% efficacy egg hatch test (EHT) larval motility (LMT), respectively. In worm test, worms were completely immobilized within first 6-8h exposition different dilutions extract. Phytochemical analysis indicated presence phenolic compounds that may be responsible observed. Moreover those results validate use natural then pharmacological potential future vivo investigations.