Evaluation of the inhibitory effect of N-acetyl-L-cysteine on Babesia and Theileria parasites

• DOI: 10.1016/j.exppara.2017.06.003
• Publication Date: 2017-06-24T12:00:46Z
• Authors: Mohamed Abdo Rizk; Shimaa Abd El-Sal...; Mahmoud AbouLaila; Naoaki Yokoyama; Ikuo Igarashi
• Keywords: Babesia bovis; Babesia bigemina; Theileria; Diminazene

N-acetyl-L-cysteine is known to have antibacterial, antiviral, antimalarial, and antioxidant activities. Therefore, the in vitro inhibitory effect of this hit was evaluated in the present study on the growth of Babesia and Theileria parasites. The in vitro growth of Babesia bovis, Babesia bigemina, Babesia divergens, Theileria equi, and Babesia caballi that were tested was significantly inhibited (P < 0.05) by micromolar concentrations of N-acetyl-L-cysteine. The inhibitory effect of N-acetyl-L-cysteine was synergistically potentiated when used in combination with diminazene aceturate on B. bovis and B. caballi cultures. These results indicate that N-acetyl-L-cysteine might be used as a drug for the treatment of babesiosis, especially when used in combination with diminazene aceturate.