Gut modulation of dysbiosis induced by dextran sulfate sodium

• DOI: 10.1016/j.fbio.2021.101167
• Publication Date: 2021-06-08T07:36:00Z
• Authors: Samat Kozhakhmetov; Dmitriy Babenko; Saniya Kozhakhmetova; Altynay Tuyakova; Madiyar Nurgaziyev; Ayaulym Nurgozhina; Nurislam Muhanbet...; Laura Chulenbayeva; Shynggys Sergazy; Alexander Gulyayev; Baimakhan Tanabayev; Timur Saliev; Almagul Kushugulova
• Keywords: Dysbiosis

Inflammatory bowel disease is one of the serious burdens clinical medicine and healthcare. This study investigated potential a biological product based on mare's milk metabolites symbiotic microflora for modulation intestinal affected by dextran sulfate sodium (DSS)-induced dysbiosis. Symbiotic was isolated from stool healthy volunteers. Lysates production short-chain fatty acids screened microorganisms were mixed with milk. The activity evaluated DSS model induced colitis. Histological changes in epithelium determined. structure microbiome analysis 16S rRNA microbial sequences. examination rat tissues after application showed reduced infiltration granulocytes, macrophages, lymphocytes. results sequencing demonstrated decrease diversity microbiota full recovery observed 21 days product. structural damaged DSS. Likewise, number pathogenic decreased Representatives SCFA producing bacteria increased concentrations genus Lactobacillus.