Polymorphism in NOD2, Crohn's disease, and susceptibility to pulmonary tuberculosis

• DOI: 10.1016/j.femsim.2004.02.004
• Publication Date: 2004-04-10T09:40:04Z
• Authors: Jemima C. Stockton; Joanna M.M. Howson; Agnes A. Awomoyi; Keith P. McAdam; Jenefer M. Blackwell; Melanie J. Newport
• Keywords: Pathogenesis

The nucleotide oligomerization binding domain 2 gene (NOD2) encodes an intracellular receptor for bacterial components, which is expressed in monocytes and associated with Crohn's Disease (CD). This finding, along epidemiological evidence, supports a role infection the pathogenesis of CD. Speculation that mycobacteria are involved CD led us to investigate NOD2 susceptibility tuberculosis (TB), global public health problem caused by Mycobacterium tuberculosis. CD-associated variants were absent case-control study 640 Gambians, where rare. Novel promoter polymorphisms identified but showed no association TB this African population sample.