Estrogen receptor α and β expression in uterine leiomyomas from premenopausal women

• DOI: 10.1016/j.fertnstert.2004.02.130
• Publication Date: 2004-10-12T16:41:28Z
• Authors: Artur J. Jakimiuk; Michal Bogusiewicz; Rafal Tarkowski; Piotr Dziduch; Aneta Adamiak; Andrzej Wróbel; Józef Haczyński; Denis A. Magoffin; Jerzy A. Jakowicki
• Keywords: Myometrium; Uterine Leiomyoma; Estrogen receptor alpha; Estrogen receptor beta; Progesterone receptor

To measure messenger RNA levels of estrogen receptor (ER) alpha and beta in uterine leiomyomas, normal myometrium, and endometrium.Prospective study.University hospital.Seventeen premenopausal women who underwent surgery due to symptomatic uterine leiomyomas.None.Quantitative RT-PCR was used for evaluation of ERalpha and ERbeta expression. Results were normalized to total cellular DNA.Expression of ERalpha and ERbeta did not differ between leiomyomas and myometrium; however, in both tissues, expression of ERalpha was significantly higher than that of ERbeta. Estrogen receptor-alpha expression in endometrium was lower than in leiomyomas and myometrium. In leiomyomas and endometrium, correlations between expression of ERalpha and ERbeta were found.Uterine leiomyomas, myometrium, and endometrium display distinct patterns of ER expression.