Lycium ruthenicum Murr. treatment attenuates APPswE/PS1ΔE9 mouse model-like mitochondrial dysfunction in Slc25a46 knockout mouse model

• DOI: 10.1016/j.fshw.2023.02.009
• Publication Date: 2023-03-21T19:09:11Z
• Authors: Min Wang; Tianxiong Xu; Li Gao; Chujun Huang; Piao Xu; Congcong Gong; William Kwame Amakye; Linfeng Liao; Maojin Yao; Jiaoyan Ren
• Keywords: Knockout mouse

Mitochondrial dysfunction is proposed to be substantially associated with ageing and ageing-related diseases like Alzheimer's disease (AD). However, it unclear whether different mouse models mitochondrial-related have similar changes in mitochondrial morphology of the same tissues. Moreover, similarities can a suitable marker for screening and/or discovering mitochondrial-protective substances remains unknown. Mitochondria tissues novel outer membrane protein Slc25a46 knockout traditional APPSWE/PS1ΔE9 transgenic were examined using transmission electron microscope (TEM). Both young mice aged showed damage cerebellum The results indicated that shared alteration defects morphology. Furthermore, Lycium ruthenicum Murr. extract, bioactive food substance cognition-improving property, could effectively improve muscle strength increase body weight mice. These findings suggest models, particularly compartment, represent unified effective validating natural product-derived functional protective properties. It also holds potential application mitochondrial-impaired senile neurodegenerative diseases, especially AD.