The regulatory role of m6A modification in the maintenance and differentiation of embryonic stem cells

• DOI: 10.1016/j.gendis.2023.101199
• Publication Date: 2023-12-19T04:31:11Z
• Authors: Jin Zhang; Lingling Tong; Yuchen Liu; Xiang Li; Jiayi Wang; Ruoxin Lin; Ziyu Zhou; Yunbing Chen; Yanxi Chen; Yirong Liu; Di Chen
• Keywords: Embryonic stem cell; m6A modification; Medicine (General); 0303 health sciences; 03 medical and health sciences; Cell-fate transition; Epigenetic modification; R5-920; Post-transcriptional regulation; Genetics; Review Article; QH426-470

As the most prevalent and reversible internal epigenetic modification in eukaryotic mRNAs, N6-methyladenosine (m6A) post-transcriptionally regulates processing metabolism of mRNAs involved diverse biological processes. m6A is regulated by writers, erasers, readers. Emerging evidence suggests that plays essential roles modulating cell fate transition embryonic stem cells. Mechanistic investigation maintenance differentiation critical for understanding early development, which also premise application cells regenerative medicine. This review highlights current knowledge its regulatory contribution to mouse human