Inflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil

• DOI: 10.1016/j.gene.2023.147325
• Publication Date: 2023-03-02T16:38:50Z
• Authors: Milena Neira-Goulart; Nathalia Beatriz ...; Marcelo Ribeiro-A...; Hugo Perazzo; Kim Mattos Geraldo; Maria Pia Diniz R...; Sandra Wagner Car...; Beatriz Grinsztejn; Valdiléa G. Veloso; Larissa Rodrigues...; Andressa da Silva...; Dalziza Victalina...; Carmem Beatriz Wa...; Fernanda Heloise ...; Mariza Gonçalves ...
• Keywords: 2019-20 coronavirus outbreak

COVID-19 has a broad spectrum of clinical manifestations. We assessed the impact single nucleotide polymorphisms (SNPs) inflammasome genes as risk factors for progression to critical outcomes, such mechanical ventilation support (MVS) or death. The study included 451 hospitalized individuals followed up at INI/FIOCRUZ, Rio de Janeiro, Brazil, from 06/2020 03/2021. SNPs genotyping was determined by Real-Time PCR. analyzed MVS (n = 174[38.6 %]) death 175[38.8 result Cox proportional hazard models. Slower associated with allele G (aHR 0.66;P 0.005) genotype G/G 0.391;P 0.006) in NLRP3 rs10754558 0.309;P 0.004) IL1β rs1143634, while C rs4612666 2.342;P 2.957;P were faster 0.563;P A/G 0.537;P CARD8 rs6509365; A/C IFI16 rs1101996 0.569;P 0.011); T/T 0.394;P T 0.68;P rs4612666, and 0.326;P 0,68;P 0.014) rs10754558. Our results suggest that genetic variations might influence course COVID-19.