Chemically reduced graphene oxide sheets for voltammetric determination of ciprofloxacin in biological fluids and pharmaceutical formulations

• DOI: 10.1016/j.hazadv.2023.100356
• Publication Date: 2023-08-10T17:35:37Z
• Authors: M. Azriouil; A. Loudiki; F. Laghrib; Y. El Bouabi; S. El Houssame; A. Farahi; M. Bakasse; S. Lahrich; M.A. EL Mhammedi
• Keywords: Repeatability; Graphite oxide; Pharmaceutical formulation

In the present work, graphene oxide (GO) reduced by ethyl acetate was used as modifier of graphite electrode (rGO-CPE) for determination Ciprofloxacin (Cipro). The rGO-CPE characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM). electrochemical behavior Cipro performed in phosphate buffer solution (0.1 mol/L PBS, pH 7). Under optimized parameters, obtained detection limit is (DL=2.18 × 10−9 mol/L). developed sensor showed excellent repeatability, estimated terms relative standard deviation to be (RSD = 2.917%), n=8, has been successfully applied recognition urine pharmaceutical formulations samples.