Large-scale phenotyping of noise-induced hearing loss in 100 strains of mice

• DOI: 10.1016/j.heares.2015.12.006
• Publication Date: 2015-12-18T11:02:23Z
• Authors: Anthony Myint; Cory H. White; Jeffrey D. Ohmen; Xin Li; Juemei Wang; Joel Lavinsky; Pezhman Salehi; Amanda L. Crow; Takahiro Ohyama; Rick A. Friedman
• Keywords: 570; Hearing Tests; 610; Disease Models, Animal; 03 medical and health sciences; Phenotype; 0302 clinical medicine; Acoustic Stimulation; Hearing; Hearing Loss, Noise-Induced; Species Specificity; Evoked Potentials, Auditory, Brain Stem; Animals; Genetic Predisposition to Disease; Auditory Fatigue; Noise; Brain Stem

A cornerstone technique in the study of hearing is the Auditory Brainstem Response (ABR), an electrophysiologic technique that can be used as a quantitative measure of hearing function. Previous studies have published databases of baseline ABR thresholds for mouse strains, providing a valuable resource for the study of baseline hearing function and genetic mapping of hearing traits in mice. In this study, we further expand upon the existing literature by characterizing the baseline ABR characteristics of 100 inbred mouse strains, 47 of which are newly characterized for hearing function. We identify several distinct patterns of baseline hearing deficits and provide potential avenues for further investigation. Additionally, we characterize the sensitivity of the same 100 strains to noise exposure using permanent thresholds shifts, identifying several distinct patterns of noise-sensitivity. The resulting data provides a new resource for studying hearing loss and noise-sensitivity in mice.