Understanding molecular markers in recurrent oral squamous cell carcinoma treated with chemoradiation

• DOI: 10.1016/j.heliyon.2016.e00206
• Publication Date: 2016-12-05T13:45:23Z
• Authors: Seema Gupta; Vandana Singh Kus...; Sandeep Verma; Huma Khan; M.L.B. Bhatt; Nuzhat Husain; Mahendra Pal Sing...; Vivek Vidyadhar B...; Ashim Ghatak
• Keywords: OPLS

IntroductionOral cancer accounts for approximately 2.1% of all cancers worldwide. In India, oral squamous cell carcinoma (OSCC) is the most common with half a million new cases diagnosed every year. More than 50% patients eventually develop local recurrence or metastasis usually within first 2-years following completion treatment. It beneficial to analyze prognostic significance Cyclin D1, p53 and EGFR which are critical mediators in pathogenesis OSCC. The objective this study was assess association expression these markers pattern OSCC undergoing chemoradiation.Materials MethodsA Total 290 locally advanced stage (III, IV) World Health Organization (W.H.O.) performance status grade 0/1 year 2009–2012 were enrolled study. Treatment response assessed according W.H.O. criteria. tumor tissue estimated by immunohistochemical (IHC) method quantified as percentage positive nuclei.ResultsDuring follow up, 56 (19.3%) recurred, out which, 47 (83.9%) locoregional 9 (16.1%) distant sites. On correlating, χ2 test showed significant (P < 0.05 P 0.01 0.001) marker expressions (Cyclin p53) recurrence. strong three early time multivariate logistic regression analysis primary site, differentiation, D1 indicating an independent predictors also poor survivals (OS, DFS RFS) positive/strong negative suggesting their prognosis OSCC.ConclusionOur results signifies that tumors over expressing resistant chemoradiation associated increased risk chemoradiation.