Codon usage similarity between viral and some host genes suggests a codon-specific translational regulation

• DOI: 10.1016/j.heliyon.2020.e03915
• Publication Date: 2020-05-08T00:14:13Z
• Authors: Kunlakanya Jitobaom; Supinya Phakarats...; Thanyaporn Siriho...; Sasithorn Chotewu...; Prapat Suriyaphol; Ornpreya Suptawiwat; Prasert Auewarakul
• Keywords: Translational efficiency

The codon usage pattern is a specific characteristic of each species; however, the all genes in genome not uniform. Intriguingly, most viruses have patterns that are vastly different from optimal their hosts. How viral with efficiently expressed during infection unclear. An analysis similarity between and individual host has never been performed. In this study, we demonstrated human RNA similar to some genes, especially those involved cell cycle. This finding was substantiated by its concordance previous reports an upregulation at protein level these biological processes. It therefore suggests suboptimal may actually be compatible cellular translational machineries infected conditions.