Simulated gastrointestinal digestion of Brazilian açaí seeds affects the content of flavan-3-ol derivatives, and their antioxidant and anti-inflammatory activities

• DOI: 10.1016/j.heliyon.2020.e05214
• Publication Date: 2020-10-13T12:18:55Z
• Authors: Priscilla Siqueir...; Adna Prado Massar...; Josy Goldoni Laza...; Jackeline Cintra ...; Marcelo Franchin; Pedro Luiz Rosalen; Severino Matias d...
• Keywords: Digestion; Flavan

Açaí seeds (Euterpe oleracea Mart.) are the major residue generated during industrial extraction of açaí fruit pulp - a popular and typical Amazon rich in bioactive compounds nutrients. In this study, we investigated bioaccessibility an seed extract using vitro simulated gastrointestinal digestion model. Catechin, epicatechin procyanidins B1 B2 were identified quantified monitored by HPLC-DAD through phases. Bioaccessibility these flavan-3-ols deactivation reactive oxygen species decreased after intestinal phase, except for peroxyl radical (ROO●). RAW 264.7 macrophages treated either with digested or undigested showed reduced NF-κB activation TNF-α levels, even following digestion. Thus, ROO● scavenging capacity anti-inflammatory activity found to be still remarkable digestion, suggesting that could explored as source functional foods, cosmetic pharmaceutical purposes.