Nanoemulsion of Minthostachys verticillata essential oil. In-vitro evaluation of its antibacterial activity

• DOI: 10.1016/j.heliyon.2021.e05896
• Publication Date: 2021-01-19T20:40:12Z
• Authors: M.E. Cecchini; C. Paoloni; N. Campra; N. Picco; M.C. Grosso; M.L. Soriano Perez; F. Alustiza; N. Cariddi; R. Bellingeri
• Keywords: Science (General); Nanoemulsions; ANTIBACTERIAL ACTIVITY; Essential oil; Q1-390; 0404 agricultural biotechnology; Nanoemulsion; Nanoemulsiones; MINTHOSTACHYS VERTICILLATA; https://purl.org/becyt/ford/2; Minthostachys verticillata; H1-99; Antimicrobial Properties; NANOEMULSION; Essential Oils; Minthostachys; 04 agricultural and veterinary sciences; Aceites Esenciales; 6. Clean water; 3. Good health; Social sciences (General); ESSENTIAL OIL; Muna; Antibacterial activity; Propiedades Antimicrobianas; https://purl.org/becyt/ford/2.10; Research Article

Infectious diseases constitute a problem of great importance for animal and human health, as well the increasing bacterial resistance to antibiotics. In this context, medicinal plants emerge an effective alternative replace use The essential oil (EO) Minthostachys verticillata (Griseb.) Epling (Lamiaceae) has demonstrated strong antimicrobial activity. However, its instability hydrophobicity under normal storage conditions are limitations use. Nanoemulsion technology is excellent way solubilize, microencapsulate, protect compound. This study aimed obtain nanoemulsion based on M. EO evaluate antibacterial activity against Staphylococcus aureus. was obtained by steam distillation. Identification quantification their components were determined GC-MS revealing that dominated chemical group oxygenated monoterpenes. Nanoemulsions (NE) characterized measuring pH, transmittance, separation percentage, release profile, morphology. effect NE growth S. aureus cyto-compatibility also evaluated. results showed containing higher percentage tween 20 exhibited stability with approximated droplet size 10 nm. encapsulation process evaluated volatile in no affected. After 24 h, 74.24 ± 0.75% released from enhanced considerably encapsulation. incubation pure EO, show inhibition 58.87% 0.99 46.72% 3.32 (p < 0.05), respectively. addition, nanoemulsión did not cause toxicity porcine equine red blood cells. could be potential vehicle promissory properties tool developing advanced therapies control combat infections.