Protective effect of Vernonia amygdalina Delile against doxorubicin-induced cardiotoxicity

• DOI: 10.1016/j.heliyon.2021.e07434
• Publication Date: 2021-06-29T15:50:48Z
• Authors: R.A. Syahputra; U. Harahap; A. Dalimunthe; M. Pandapotan; D. Satria
• Keywords: Vernonia amygdalina; Cardiotoxicity

Doxorubicin has been used as an anticancer drug and already indicated effective in the treatment of cancer. The incidence cardiotoxicity due to doxorubicin was approximately 11%, resulting limited use doxorubicin. Cardiac protection during therapy is needed because it can reduce heart failure. Vernonia amygdalina (VA) traditionally by Indonesians a traditional medicine contains many secondary metabolites, including vernolide, vernodalol, vernoamygdalin, vernolepin, luteolin, luteolin 7-O-beta-glucoronoside 7-O-glucoside. pharmacological activity VA widely studied, its antimalarial, antidiabetic, anticancer, hepatoprotective, nephroprotective, antioxidant activities. This research aimed determine 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, total phenol, flavonoid, cardioprotective effects Amygdalina. Negative control only intraperitoneal injection (20 mg/kgbw) on eight day while quercetin (85 ethanol extract (EEVA) 100, 200, 400 mg/kgbw dose are orally administered for consecutive days. Both EEVA groups were also injected with same day. On following day, rats ketamine HCL 75 dissected blood collected. collected 3 ml from each rat analyzed biochemical parameters. parameters Aspartate transaminase (AST), Alanine (ALT), Ureum, Creatinine, Creatinine kinase-MB (CK-MB), Lactate dehydrogenase (LDH), Troponin T, Brain natriuretic peptide (BNP), parameter Superoxide Dismutase (SOD). result showed that 40.51 ± 4.89 μg/mL, flavonoid 3.79 0.61 mg QE/g extract, phenol 281.575 1.069 GAE/g extract. Quercetin (400 AST, ALT, CK- MB, LDH, BNP significantly increase rats' SOD level compared negative control. So that, this study explicates potentials agent against reducing