Synthesis and characterization of bovine serum albumin-coated copper sulfide nanoparticles as curcumin nanocarriers

• DOI: 10.1016/j.heliyon.2023.e13740
• Publication Date: 2023-02-14T22:15:46Z
• Authors: Ali Mohammadi; Hossein Danafar
• Keywords: Nanocarriers; Bovine serum albumin; Copper sulfide; Characterization

Cancer is among the most common causes of death in world that affects a large number people every year. Curcumin one natural anticancer therapeutics with little or no negative effects. However, due to its hydrophobic nature, poor bioavailability, limited gastrointestinal uptake, and fast metabolism, therapeutic applications are constrained. Therefore, Bovine Serum Albumin-Coated Copper Sulfide anoparticles (CuS@BSA) for curcumin (CUR) drug delivery were synthesized characterized, then release from nanosystem. Hemotoxicity, cytotoxicity was investigated. This study involved one-step synthesis CuS@BSA nanoparticles first, followed by addition CUR. Then characterized employing Scanning Transient Electron Microscopy (STEM), Ultraviolet-visible spectroscopy (UV-vis) Fourier-transform infrared (FT-IR) techniques. The Size surface charge (zeta potential) determined Dynamic Light Scattering (DLS) be 120 nm -13 eV, respectively. results showed CUR loading around 15% also pattern dependent on pH increased an acidic environment. hemolysis assay not hemotoxic. investigation cytotoxic effects cancer cells demonstrated did exhibit any toxicity therefore appropriate candidate delivery.