Subclinical cardiac involvement present as electrocardiographic abnormalities in various neuromuscular diseases

• DOI: 10.1016/j.heliyon.2023.e13940
• Publication Date: 2023-02-23T04:38:55Z
• Authors: Nanqing Xiong; Weizhuo Liu; Jian Li; Sushan Luo; Wentao Gu; Wenhua Zhu; Jianying Xi; Jie Lin; Bangwei Wu; Xinping Luo
• Keywords: H1-99; Science (General); Ventricular hypertrophy; Conduction block; QT prolongation; Neuromuscular disease; 3. Good health; Social sciences (General); Q1-390; 03 medical and health sciences; Subclinical cardiac involvement; 0302 clinical medicine; Research Article

Cardiac involvement is commonly present in various neuromuscular diseases which may develop life-threatening consequences. The early manifestation is often asymptomatic which however has been insufficiently studied.We aim to characterize electrocardiographic (ECG) changes in neuromuscular diseases without cardiac symptoms.Adults having genetically and/or pathologically confirmed type 1 myotonic dystrophy (DM1), Becker muscular dystrophy (BMD), limb girdle muscular dystrophies (LGMDs) and mitochondrial diseases (MtDs) but without history of heart diseases and cardiovascular symptoms were enrolled. The 12-lead ECG characteristics and other test results at diagnosis were retrieved and analyzed.196 patients with neuromuscular diseases (44 DM1, 25 BMD, 82 LGMDs, 45 MtDs) were consecutively enrolled. ECG abnormalities were identified in 107 (54.6%) patients with a prevalence of 59.1% in DM1, 76.0% in BMD, 40.2% in LGMDs and 64.4% in MtDs. Conduction block was more commonly present in DM1 than the other groups (P < 0.01), which had a longest PR interval and QRS duration of 186.1 ± 38.3 ms and 104.2 [90.0-108.0]ms, respectively. QT prolongation was most frequently seen in DM1 (P < 0.001). Left ventricular hypertrophy features were found in BMD, LGMDs and MtDs (P < 0.05) without intergroup difference, while a significantly higher right ventricular amplitude is observed in BMD than in other groups (P < 0.001).Subclinical cardiac involvement is commonly present as ECG abnormalities in multiple adult neuromuscular diseases before associated symptoms occur and show diversity in different groups.