Biomarkers for the severity of periodontal disease in patients with obstructive sleep apnea:IL-1 β, IL-6, IL-17A, and IL-33

• DOI: 10.1016/j.heliyon.2023.e14340
• Publication Date: 2023-03-14T07:46:15Z
• Authors: Mayra A. Téllez C...; Eddy Herrera Daza; Natalia Arango Ji...; Darena Z. Morales...; Juliana Velosa Po...; Catalina Latorre ...; Francina M. Escob...; Patricia Hidalgo ...; María E. Cortés; Liliana Otero; Claudia M. Parra ...; Nelly S. Roa Molina
• Keywords: Interleukin 8

This study aims to compare the salivary and gingival crevicular fluid (GCF) concentrations of five cytokines: IL-1β, IL-6, IL-17A, IL-33, Tumor Necrosis Factor-alpha (TNF-α) in patients with OSA their association periodontitis.Samples saliva GCF were obtained from 84 classified into four groups according periodontal diagnosis: G1(H) healthy patients, G2(P) periodontitis non-OSA G3(OSA) non-periodontitis G4(P-OSA) patients. The cytokines samples quantified using multiplexed bead immunoassays. Data analyzed Kruskal-Wallis test, Dunn's multiple comparisons Spearman correlation test.Stage III was highest severe (69%; p=0.0142). Similar levels IL-1β IL-6 noted G4(P-OSA). IL-17A IL-33 higher There a significant positive between stage IV (rs = 0.531). cytokine profile Candida spp. had an increase cytokine's compared who did not have yeast.OSA may risk developing due that share activation osteoclastogenesis. Those be considered as biomarkers periodontitis.