Treatment of persistent chemotherapy-induced hair loss (Alopecia) with human mesenchymal stromal cells exosome enriched extracellular vesicles: A case report

• DOI: 10.1016/j.heliyon.2023.e15165
• Publication Date: 2023-04-01T15:36:25Z
• Authors: Amir Hossein Noro...; Reza Yarani; Mehrdad Payandeh; Zohreh Hoseinkhani; Hamidreza Mahmoudi; Sarah Kiani; Kamran Mansouri
• Keywords: Extracellular Vesicles; Exosome

Cancer is among the leading causes of death worldwide and affects a considerable number individuals. Chemotherapy one most common treatment for this condition hair loss prevalent side effects. In study, we report successful patient suffering from persistent chemotherapy-induced alopecia (PCIA) with extracellular enriched vesicles (EVs) derived human placental mesenchymal stromal cells (MSCs).The was 36-year-old woman history invasive ductal carcinoma, underwent six courses chemotherapy paclitaxel adriamycin. Following almost 18 months, she, unfortunately, had no regrowth except some light vellus hairs on scalp. She then received MSC-derived EVs scalp injection (subcutaneous) every 4 weeks 3 continuous months at which point she presented complete terminal her scalp.This demonstrates that could be possible permanent alopecia; however, further studies trials are necessary.