Spider diagram and sustainability evaluation of UV-methods strategy for quantification of aspirin and sildenafil citrate in the presence of salicylic acid in their bulk and formulation

• DOI: 10.1016/j.heliyon.2023.e15260
• Publication Date: 2023-04-06T00:13:35Z
• Authors: Zahraa Kayali; Reem H. Obaydo; Amir Alhaj Sakur
• Keywords: AGREE; Social sciences (General); H1-99; Q1-390; Complex GAPI; Science (General); Aspirin; Sildenafil citrate; Salicylic acid; UV-methods; 3. Good health; Research Article

The cutting-edge combination of aspirin (ASA) and sildenafil citrate (SIC) has been presented as a suggested dosage form for the treatment thin endometrium erectile dysfunction, particularly in patients with cardiovascular diseases. However, ASA is highly sensitive to degradation into its major deterioration product, known salicylic acid (SA). Consequently, it eminently essential evolve approaches synchronous quantification SIC presence SA.The main objective this work develop three SA their commixtures formulations without any prior separation.Three green UV-methods were employed quantification, namely: Dual Wavelength Ratio Spectra (DW-RS), Advanced Amplitude Centering (AAC), Double Divisor Difference Derivative (DDRD-D1). In DW-RS AAC two-wavelength manipulation was used resolution, while DDRD-D1 only an appropriate wavelength triplex commixture used. All can be able resolve interfering spectrum components commixture.Good linearity inspected range 20.0–100.0, 5.0–50.0, 4.0–60.0 μg/mL ASA, SIC, SA, respectively.All developed have advocated accordance ICH guidelines.All results from these are statistically reconciled proclaimed HPLC method, no considerable differences.Furthermore, approaches' eco-friendliness predestined by Analytical Greenness (AGREE), complex GAPI.Moreover, sustainability solvent evaluated Green Solvents Selecting Tool (GSST); addition, greenness Index tool spider diagram.The may routine quality control studies & since they considered sustainable, economical, effective.