CILP2: A prognostic biomarker associated with immune infiltration in colorectal cancer

• DOI: 10.1016/j.heliyon.2023.e15535
• Publication Date: 2023-04-20T10:20:15Z
• Authors: Xueli Wang; Yu Zhang; Niping Song; Kaiqiang Li; Siyun Lei; Jianwei Wang; Zhen Wang; Wei Zhang
• Keywords: KEGG; Immune checkpoint

The function played by cartilage intermediate layer protein 2 (CILP2) between colorectal cancer (CRC) progression and immune response remains unclear, especially with respect to cell infiltration checkpoints. Materials Methods: We examined CILP2 expression in Cancer Genome Atlas (TCGA) COAD-READ cohort analyzed its relationship clinicopathological features, mutations, survival, immunity. Gene ontology, Kyoto Encyclopedia of Genes Genomes pathway analysis, gene set enrichment analyses (GSEA) were performed determine related pathways. To further investigate the results TCGA validation was using CRC lines, fresh pathological tissues, a tissue microarray (TMA). Results: In both TMA cohorts, increased tissues associated patient T stage (T3 T4), N (N1), (III IV), overall survival. Immune checkpoint analysis revealed that is highly correlated multiple marker genes, including PD-1. addition, indicated genes mainly enriched extracellular matrix functions. Conclusion: Elevated adverse clinical features cells, it has potential as biomarker detrimental