The effect of antibiotic prophylaxis on the incidence of surgical site infection after laparoscopic appendectomy for chronic appendicitis

• DOI: 10.1016/j.heliyon.2023.e15578
• Publication Date: 2023-04-24T16:12:31Z
• Authors: Li Dai; Xiangren Jin; Haitao Xie; Tong He; Honggang Cheng; Yinwu Zhu; Liuxing Wang; Fu Huang; Baichuang Liang; Xin Gou; Qian Wang; Haibin Wang
• Keywords: Cefuroxime

The guidelinesthat specify whether antibiotic prophylaxis should be administered before laparoscopic clean-contaminated wound to prevent postoperative surgical site infection (SSI) need improved. Studies have shown that elective cholecystectomy with does not require prophylaxis. However, there are no studies on the effect of SSI after appendectomy for chronic appendicitis (LCA), which is a wound.We conducted single-center, double-blind, randomized controlled clinical trial. A total 106 effective patients were randomly divided into group and saline group. Cefuroxime or clindamycin was intravenously in (n = 52). Saline (0.9%) 54). Interventions as single dose 30 min surgery.Among (median age, 37 years old [IQR, 25-45]; females, 77 [72.6%]), 6 cases (5.70%) SSI: 3 (5.56%) (OR 1.00, [95% CI (0.20-5.4)], P 0.96). There significant differences outcomes anal exhaust time, complications, symptom primary abdominal pain between two groups.For undergoing appendectomy, preoperative intravenous did reduce risk within days surgery compared group.Registration number China Clinical Trials Registration Center: ChiCTR2100048336.