The determinants of thyroid function among vegetable farmers with primary exposure to chlorpyrifos: A cross-sectional study in Central Java, Indonesia

• DOI: 10.1016/j.heliyon.2023.e16435
• Publication Date: 2023-05-23T21:51:18Z
• Authors: Jen Fuk Liem; Imam Subekti; Muchtaruddin Mansyur; Dewi S. Soemarko; Aria Kekalih; Franciscus D. Suy...; Dwi A. Suryandari; Safarina G. Malik; Bertha Pangaribuan
• Keywords: Thyroglobulin; Thyroid-stimulating hormone

Occupational pesticide exposure, chlorpyrifos (CPF) in particular, may adversely affect the thyroid. The purpose of this study was to evaluate determinants thyroid function as indicated by serum concentration thyroid-stimulating hormone (TSH) among Indonesian vegetable farmers with primary exposure CPF.A total 151 participated study. sociodemographic and occupational characteristics participants were obtained using a structured interviewer-administered questionnaire. A validated quantitative method used estimate cumulative level (CEL). Serum TSH, thyroglobulin (Tg), free thyroxine (FT4), urinary iodine excretion (UIE) measured laboratory. difference TSH concentrations according CEL other analysed Mann-Whitney U test. multiple linear regression model potential TSH.The mean age 50 (SD 9.4) years. median FT4, Tg/FT4 ratio 1.46 mIU/L, 1.17 ng/dL, 6.23 × 102, respectively. We observed that higher found those ratio, classified high CEL, had lower UIE or FT4.Our findings show concentrations, post-spraying days CPF. These results indicate are exposed agents thyroid-disrupting properties, thus supporting previous evidence showing for disorders agricultural populations pesticides.