The efficacy and safety of low-molecular-weight heparin in patients undergoing knee arthroscopic surgery and anterior cruciate ligament reconstruction

• DOI: 10.1016/j.heliyon.2023.e19696
• Publication Date: 2023-09-06T12:20:12Z
• Authors: Hui-Min Li; Leyi Huang; Junwei Fu; Zhicheng Tong; Wei Wei; Chong Teng
• Keywords: Knee surgery

PurposeTo inveatigate how effective LMWH was at preventing venous thromboembolism (VTE), major bleeding events, and minor events after simple knee arthroscopic surgery anterior cruciate ligament reconstruction (ACLR).MethodsWe conducted a comprehensive search of PubMed, EMBASE, Cochrane Library, the CNKI database for potentially eligible articles. The outcomes were evaluated in terms odds ratio (OR) associated 95% confidence intervals (CIs). Meta-analysis performed using Stata software subgroup analyses based on surgical setting including ACLR surgery.ResultsA total eight studies with 2249 patients 1794 controls included this meta-analysis. In undergoing surgery, prophylaxis did not bring significant reduction risk symptomatic deep thrombosis (DVT), pulmonary embolism (PE), VTE, increase but have higher (OR = 1.95, CI 1.34–2.84, P 0.000) lower asymptomatic DVT 0.14, 0.04–0.53, 0.004) comparison non-LMWH prophylaxis. ACLR, DVT, PE, 0.43, 0.23–0.78, 0.006).ConclusionWhen compared to control group, meta-analysis found that had little potential benefit VTE (symptomatic PE) arthroscopy ACLR. As result, should be considered routinely surgery.