Psychiatric disorders and cardiovascular diseases: A mendelian randomization study

• DOI: 10.1016/j.heliyon.2023.e20754
• Publication Date: 2023-10-06T16:17:33Z
• Authors: Xiaohui Sui; Tingting Liu; Yi Liang; Baoqing Zhang
• Keywords: Mendelian Randomization; Stroke; Genome-wide Association Study

Previous researches have demonstrated a connection between psychiatric disorders and cardiovascular diseases (CVDs), but the cause-and-effect relationship is still unclear. To that goal, mendelian randomization (MR) method was used to study causal link CVDs.Genome-wide association studies (GWAS) data were collected for four CVDs, including coronary artery disease (n = 547,261), atrial fibrillation 537,409), heart failure 977,323) ischemic stroke 440,328). Summary disorders, bipolar disorder 51,710), major depressive 480,359), schizophrenia 127,906) attention deficit hyperactivity 55,374), came from Psychiatric Genomics Consortium (PGC). All participants European. The IVW mainly used, reliability of results increased using sensitivity analyses such as MR-Egger, Cochrane's Q test, MR-PRESSO leave-one-out.MR revealed linked an risk (OR, 1.085; 95% CI, 1.021-1.153; P 0.008), 1.117; 1.044-1.195; 0.001), 1.146; 1.052-1.248; 0.002). 1.035; 1.006-1.066; 0.017), found be suggestively inverse associated with 0.969; 0.941-0.997; 0.03). higher odds 1.109; 1.018-1.208; 0.018), while reduced incidence 0.894; 0.831-0.961; 0.002) 0.889; 0.829-0.955; 0.001). There no clear relationships other CVDs.The provide genetic proof possible CVDs. These imply may cause some abnormal mental states increase or reduce likelihood providing guidance CVDs prevention.