Acute and subacute hepatotoxicity of genipin in mice and its potential mechanism

• DOI: 10.1016/j.heliyon.2023.e21834
• Publication Date: 2023-11-04T03:07:41Z
• Authors: Shuaikang Wang; Shuchao Ge; Yaohui Chen; Feng Zhou; Jingjing Wang; Liping Chen; Yinfang Chen; Riyue Yu; Liping Huang
• Keywords: Genipin; Gardenia jasminoides

Gardenia, as a medicinal and edible herb, has the pharmacological activity of protecting liver cholagogue, but hepatotoxicity induced by chemical component genipin (GP) limits its application. The aim this study was to evaluate acute subacute in normal mice with α-naphthalene isothiocyanate (ANIT)-induced injury. results showed that LD50 510 mg/kg. Genipin exhibited jaundiced at doses 125 mg/kg, 250 500 which increased dose. In 28-day study, 50 mg/kg 100 dose groups some pharmacodynamic effects 7 days time improved after drug withdrawal. addition, based on proteomics, mechanism injury may be related disruption UDP-glucuronosyltransferase system cytochrome P450 enzyme activity. conclusion, time- dependent, it is worth mentioning reversible. It hoped will provide scientific basis for circumventing adverse genipin.