Association of serum tumor markers with serous effusion in systemic lupus erythematosus

• DOI: 10.1016/j.heliyon.2023.e23213
• Publication Date: 2023-12-03T02:18:58Z
• Authors: Ying Zhong; Jinlu Ma; Lin Zhang; Zhichun Liu; Leixi Xue
• Keywords: Carcinoembryonic antigen; Serositis; Meigs' syndrome

The objective of this study was to investigate the relationship between serum tumor markers and serous effusion in systemic lupus erythematosus (SLE) patients, thereby contributing preliminary data on utility these diagnosing effusion. In retrospective analysis, clinical SLE patients were extracted from electronic medical records. This included levels markers, including pro-gastrin-releasing peptide, neuron-specific enolase (NSE), cytokeratin-19 fragments (CYFRA 21-1), various carbohydrate antigens (CA 153, CA 125, 19-9), along with carcinoembryonic antigen, alpha-fetoprotein. Positivity established based surpassing upper threshold respective reference ranges. 149 eligible SLE, whom 38 (25.50%) had effusion, prevalence pleural, pericardial, peritoneal effusions 11.41%, 14.77%, 6.71%, respectively. analysis revealed that higher scores Disease Activity Index 2000 (SLEDAI 2000) than those without Notably, disparity remained significant when serositis score excluded SLEDAI calculation. positivity rate 125 pleural Patients pericardial demonstrated an elevated CYFRA 21-1 compared NSE both terms for Through receiver operating characteristic curve a moderate discerned conjoined occurrence Additionally, NSE, their combination diagnostic ability summary, observed exhibiting which is likely attributable lupus-induced inflammation. These findings suggest can be valuable effusions.