Apelin ameliorates sepsis-induced myocardial dysfunction via inhibition of NLRP3-mediated pyroptosis of cardiomyocytes

• DOI: 10.1016/j.heliyon.2024.e24568
• Publication Date: 2024-01-23T17:22:22Z
• Authors: Zhi Cao; Weifeng Li; Zhuang Shao; Xinqiang Liu; Yi Zeng; Peijun Lin; Chuangqiang Lin; Yuechu Zhao; Ting Li; Zichao Zhao; Xin Li; Yuelin Zhang; Bei Hu
• Keywords: Pyroptosis; Apelin

Sepsis-induced myocardial dysfunction (SMD) is the major cause of death in sepsis. Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3)-mediated pyroptosis contributes to occurrence and development SMD. Although Apelin confers direct protection against SMD, potential mechanisms remain unclear. This study aimed determine whether protects SMD via regulation NLRP3-mediated cardiomyocytes. Experimental was induced wild-type (WT) control mice knockout (Apelin